background:
MAL (myelin and lymphocyte protein), also known as T lymphocyte maturation-associated protein, is a nonglycosylated hydrophobic integral membrane protein belonging to the Myelin and lymphocyte (MAL) family of proteolipids. MAL is highly enriched in nervous system myelin and in rafts and apical membranes of epithelial cells. It is involved in forming, stabilizing and maintaining glycosphingolipid-enriched membrane microdomains. MAL maintains the myelin sheath and, by controlling the sorting and trafficking of oligodendrocytes, it is involved in central nervous system paranode maintenance. MAL is a component of lipid rafts in myelinating cells. Association with glycosphingolipids may result in protein-lipid microdomain formation in myelin. MAL has been localized to the endoplasmic reticulum of T cells and in compact myelin of cells in the nervous system. MAL is primarily expressed by oligodendrocytes and Schwann cells in the intermediate and late stages of T cell differentiation.
Function:
Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Post-translational modifications:
Lipoprotein.
Similarity:
Belongs to the MAL family.
Contains 1 MARVEL domain.
Database links:
Entrez Gene: 4118 Human
Entrez Gene: 17153 Mouse
Entrez Gene: 25263 Rat
Omim: 188860 Human
SwissProt: Q28296 Dog
SwissProt: P21145 Human
SwissProt: O09198 Mouse
SwissProt: Q64349 Rat
Unigene: 80395 Human
Unigene: 39040 Mouse
Unigene: 10174 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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