background:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. NOD9, also known as NLRX1, NOD26 or NOD5, is a 975 amino acid outer mitochondrial membrane protein that contains one NACHT domain and four LRR repeats. Expressed at high levels in heart, muscle and mammary gland, NOD9 plays a role in antiviral signaling, specifically via inhibition of virus-induced helicases, thereby acting as a negative regulator of antiviral responses. Two isoforms of NOD9 exist due to alternative splicing events.
Function:
Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).
Subunit:
Interacts with MAVS.
Subcellular Location:
Mitochondrion outer membrane.
Tissue Specificity:
Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level).
Similarity:
Belongs to the NLRP family.
Contains 7 LRR (leucine-rich) repeats.
Contains 1 NACHT domain.
Database links:
Entrez Gene: 539974 Cow
Entrez Gene: 489370 Dog
Entrez Gene: 100071383 Horse
Entrez Gene: 79671 Human
Entrez Gene: 270151 Mouse
Entrez Gene: 315599 Rat
Omim: 611947 Human
SwissProt: Q86UT6 Human
SwissProt: Q3TL44 Mouse
SwissProt: Q5FVQ8 Rat
Unigene: 54882 Human
Unigene: 3957 Mouse
Unigene: 12444 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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