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Rabbit Anti-HSPBAP1/FITC Conjugated antibody
background:
Heat Shock Protein BAP1 (heat shock 27-kDa-associated protein 1, or HSPBAP1) inhibits the function of heat shock protein 27, which has a neuroprotective effect during experimentally induced epileptic neuropathology. The HSPBAP1 protein, also known as PASS1, contains a jmjC motif, suggesting it is a member of the jumonji family of transcription factors. There is evidence of domain swapping within the jumonji family genes, and the HSPBAP1 gene has been shown to fuse with a novel gene called DIRC3 in hereditary renal cell cancer.
Function:
May play a role in cellular stress response.
Subunit:
Interacts with CRYAB and HSPB1.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Widely expressed.
DISEASE:
Note=A chromosomal aberration involving HSPBAP1 has been found in a family with renal carcinoma. Translocation t(2;3)(q35;q21) with the putative pseudogene DIRC3. Produces an hybrid mRNA encoding a truncated HSPBAP1 lacking the first 36 amino acids.
Similarity:
Contains 1 JmjC domain.
Database links:
Entrez Gene: 79663 Human
Omim: 608263 Human
SwissProt: Q96EW2 Human
Unigene: 29169 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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