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Rabbit Anti-Coronin 1a/FITC Conjugated antibody
background:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
Function:
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
Subunit:
Binds actin.
Subcellular Location:
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.
Tissue Specificity:
Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.
Similarity:
Belongs to the WD repeat coronin family.
Contains 7 WD repeats.
Database links:
Entrez Gene: 11151 Human
Entrez Gene: 12721 Mouse
Entrez Gene: 155151 Rat
Omim: 605000 Human
SwissProt: P31146 Human
SwissProt: O89053 Mouse
SwissProt: Q91ZN1 Rat
Unigene: 415067 Human
Unigene: 290482 Mouse
Unigene: 6990 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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