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Rabbit Anti-FGF12/FITC Conjugated antibody
background:
Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithe-lial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10–FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family including four tyrosine kinases, designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.
Function:
Probably involved in nervous system development and function.
Subunit:
Interacts with the SLCterminal region of SCN9A (By similarity).
Subcellular Location:
Nucleus.
Tissue Specificity:
Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.
Database links:
Entrez Gene: 2257 Human
Entrez Gene: 14167 Mouse
Entrez Gene: 170630 Rat
Omim: 601513 Human
SwissProt: P61328 Human
SwissProt: P61329 Mouse
SwissProt: P61150 Rat
Unigene: 390250 Human
Unigene: 7996 Mouse
Unigene: 45965 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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