Rabbit Anti-FASP1/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-FASP1/FITC Conjugated antibody

B28; C21orf46; FASP1; hMis18alpha; MaFF interacting protein; MAFIP; MIS18A; Protein Mis18 alpha; MS18A_HUMAN.

Cat:

SL9738R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Dog,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human FASP1/C21orf45

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

26kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
Mapping to chromosome 21, the FASP1 gene (FAPP1-associated protein 1) encodes a 233 amino acid protein that is homologous to the fission yeast protein Mis18. In yeast, Mis18 is localized to the centrosome and forms a complex with Mis16 to maintain the deacetylated state of histones specifically in the central core of centromeres. FASP1, also known as Protein Mis18-alpha and C21orf45, is required for the recruitment of CENP-A to centrosomes and is thereby essential for normal chromosome segregation during mitosis. With expression in testis, FASP1 exists as a homodimer, a heterodimer with MIS18B or is present in a complex containing other Mis18 family members. FASP1 has been shown to bind to pp5644 in Hela cells, where overexpression of pp5644 leads to inhibited growth and colony formation.

Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Subunit:
Homodimer, and heterodimer with MIS18B. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4.

Subcellular Location:
Nucleus. Centromere.

Tissue Specificity:
Detected in testis.

Similarity:
Belongs to the mis18 family.

Database links:

Entrez Gene: 54069 Human

SwissProt: Q9NYP9 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall