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Rabbit Anti-D53/TPD52L1/FITC Conjugated antibody
background:
The cell commits to dividing during the G2/M phase transition, and the timing of mitotic entry is tightly regulated to guarantee correct chromosome segregation. D53, also referred to as tumor protein D52-like 1 (TPD52L1), is a coiled-coil motif-bearing member of the D52 tumor protein family. D53 intereacts with 14-3-3, a negative regulator of the G2/M transition, in breast cancer cells. Expression of D53 is highly upregulated at the G2/M phase transition in breast cancer cell lines, and deregulated expression of this protein can adversely affect the completion of mitosis. D53 may function as a signaling intermediate and/or regulator of vesicle trafficking and cell proliferation.
Subunit:
Forms a homodimer or heterodimer with other members of the family.
Similarity:
Belongs to the TPD52 family.
Database links:
Entrez Gene: 7164 Human
Entrez Gene: 21987 Mouse
Omim: 604069 Human
SwissProt: Q16890 Human
SwissProt: O54818 Mouse
Unigene: 591347 Human
Unigene: 439966 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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