Rabbit Anti-TSSK6/FITC Conjugated antibody

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Cancer/testis antigen 72; CT72; EC 2.7.11.1; Serine/threonine-protein kinase SSTK; Small serine/threonine kinase; Small serine/threonine protein kinase; SSTK; testis-specific serine kinase 6; Testis-specific serine/threonine kinase 6; Testis-specific seri

Cat:

SL9734R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human TSSK6/CT72

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

30kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility.

Function:
Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity).

Subunit:
Interacts with the heatshock proteins HSPCB, HSPA8 and HSPA1A. These interactions appear to be required for TSSK6 kinase activity. Interacts with TSACC; this interaction is direct and recruits TSACC to HSP90, which is essential for kinase activity.

Tissue Specificity:
Highly expressed in testis. Expressed at lower levels in colon, small intestine, ovary, prostate, thymus, spleen and peripheral blood leukocytes.

Post-translational modifications:
Autophosphorylated.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 83983 Human

Entrez Gene: 83984 Mouse

Omim: 610712 Human

SwissProt: Q9BXA6 Human

SwissProt: Q925K9 Mouse

Unigene: 532711 Human

Unigene: 432504 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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