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Rabbit Anti-PDE4A8/FITC Conjugated antibody
background:
The protein encoded by this gene belongs to the cyclicnucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. ThisPDE hydrolyzes the second messenger, cAMP, which is a regulator andmediator of a number of cellular responses to extracellularsignals. Thus, by regulating the cellular concentration of cAMP,this protein plays a key role in many important physiologicalprocesses. Alternatively spliced transcript variants encodingdifferent isoforms have been described for this gene.[provided byRefSeq, Jul 2011].
Function:
Hydrolyzes the second messenger cAMP, which is a keyregulator of many important physiological processes.
Subunit:
Isoform 1 interacts with LYN. Isoform 2 and isoform 6interact weakly with LYN. Isoform 1, isoform 2 and isoform 6interact with ARRB2.
Subcellular Location:
Isoform 1: Cytoplasm, perinuclear region.
Tissue Specificity:
Isoform 1 is widely expressed. Isoform 2 isabundant in liver, stomach, testis, thyroid and adrenal glands. Itis also found in placenta, kidney, pancreas, ovary, uterus, skin,monocytes, mast cells, macrophages, as well as in bronchial smoothmuscle. Isoform 6 is expressed at high levels in the heart andsmall intestine. It is also found in the brain, kidney, spleen,colon, salivary gland, ovary and peripheral blood lymphocytes.Isoform 7 is expressed predominantly in skeletal muscle and brainand at lower levels in the testis. Isoform 7 is expressed in thebrain. Found in specific neuronal subpopulations in cortex, spinalcord and cerebellum (at protein level).
Post-translational modifications:
Phosphorylation by MAPKAPK2 its activation through PKAphosphorylation (By similarity). Phosphorylated at Ser-686 andSer-688 when expressed in S.frugiperda cells. Isoform 2 and isoform7 are activated by phosphorylation at Ser-119 and Ser-123respectively by PKA.
Proteolytically cleaved by caspase-3.
Similarity:
Belongs to the cyclic nucleotide phosphodiesterasefamily. PDE4 subfamily.
Database links:
Entrez Gene: 5141 Human
SwissProt: P27815 Human
Unigene: 89901 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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