background:
C10orf27, also known as spatial, is a 351 amino acid cytoplasmic protein belonging to the spatial family. C10orf27 is suggested to play a role in spermatid differentiation. Existing as two alternatively spliced isoforms, C10orf27 is widely expressed in multiple tissues, including brain, thymus and testis. C10orf27 may be associated with multiple sclerosis (MS) susceptibility and pathogenesis. MS is an inflammatory disease that causes gradual destruction of myelin in the central nervous system. C10orf27 is encoded by a gene located on human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome.
Function:
May play a role in spermatid differentiation (Bysimilarity). Modulates thymic stromal cell proliferation and thymusfunction (By similarity).
Subcellular Location:
Cytoplasm,
Similarity:
Belongs to the TBATA family.
Database links:
Entrez Gene: 219793 Human
Omim: 612128 Human
SwissProt: Q96M53 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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