background:
Na+/H+ exchangers (NHEs) catalyze the transport of Na+ in exchange for H+ across membranes in organisms and are required for numerous physiological processes. NHEDC2 (Na+/H+ exchanger-like domain-containing protein 2), also known as NHA2, is a 537 amino acid mitochondrial protein. NHEDC2 is involved in organelle volume homeostasis by catalyzing the exchange of protons for Na+ and Li+ across the inner mitochondrial membrane. Found in red blood cells, NHEDC2 is required for bone resorption activity and osteoclast differentiation. As a multi-pass membrane protein, NHEDC2 is expressed as two isoforms produced by alternative splicing events.
Function:
Electroneutral exchange of protons for Na(+) and Li(+)across the inner mitochondrial membrane. Contributes to theorganellar volume homeostasis. Required for osteoclastdifferentiation and bone resorption activity (By similarity).
Subcellular Location:
Mitochondrion membrane; Multi-pass membraneprotein (By similarity).
Tissue Specificity:
Detected in red blood cells (at proteinlevel).
Similarity:
Belongs to the monovalent cation:proton antiporter 1(CPA1) transporter (TC 2.A.36) family.
Database links:
Entrez Gene: 133308 Human
Entrez Gene: 97086 Mouse
Entrez Gene: 365946 Rat
Omim: 611789 Human
SwissProt: Q86UD5 Human
SwissProt: Q5BKR2 Mouse
Unigene: 546482 Human
Unigene: 441764 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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