background:
LCE1A belongs to the late cornified envelope (LCE) genecluster within the epidermal differentiation complex (EDC) onchromosome 1. The LCE cluster contains multiple conserved genesthat encode stratum corneum proteins, and these genes are expressedrelatively late during fetal assembly of the skin cornifiedenvelope (Jackson et al., 2005 [PubMed 15854049]). For furtherinformation on the LCE gene cluster, see GENE FAMILYbelow.[supplied by OMIM, Feb 2009].
Function:
Precursors of the cornified envelope of the stratum corneum.
Tissue Specificity:
Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
Similarity:
Belongs to the LCE family.
Database links:
Entrez Gene: 353131 Human
Omim: 612603 Human
SwissProt: Q5T7P2 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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