Rabbit Anti-GERP/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-GERP/FITC Conjugated antibody

RNF27; Lioblastoma expressed ring finger protein; Ring finger protein 27; RNF27; RP11-47A8.4; TRIM8; Tripartite motif containing 8; Tripartite motif protein TRIM8; TRIM8_HUMAN.

Cat:

SL9432R-FITC

Species Reactivity：

Human,Mouse,(predicted: Rat,Chicken,Dog,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human GERP/TRIM8/RNF27

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

61kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM8 (tripartite motif containing 8), also known as GERP (glioblastoma-expressed RING finger protein) or RNF27 (RING finger protein 27), is a 551 amino acid protein that is thought to function as an E3 ubiquitin-protein ligase that promotes SOCS-1 proteasomal degradation. As a widely expressed homodimer, TRIM8 localizes to nuclear bodies and contains two B box-type zinc fingers and one RING-type zinc finger. TRIM8 is expressed in lung, heart, brain and skeletal muscle, with low levels detected in intestine, placenta, leukocytes and liver. The gene encoding TRIM8 maps to human chromosome 10q24.32.

Function:
Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.

Subunit:
Homodimer. Interacts with SOCS1 (via) SH2 domain and SOCS box.

Tissue Specificity:
Widely expressed.

Similarity:
Belongs to the TRIM/RBCC family.
Contains 2 B box-type zinc fingers.
Contains 1 RING-type zinc finger.

Database links:

Entrez Gene: 81603 Human

Entrez Gene: 93679 Mouse

Entrez Gene: 688785 Rat

Omim: 606125 Human

SwissProt: Q9BZR9 Human

SwissProt: Q99PJ2 Mouse

Unigene: 336810 Human

Unigene: 392177 Mouse

Unigene: 481672 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

葛博：SL9432R 细胞定位：细胞质细胞核 2017.11.08日张凤英修改

Product Feedback Wall