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Rabbit Anti-KCTD5/FITC Conjugated antibody
background:
The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. KCTD5 (potassium channel tetramerisation domain containing 5) is a 234 amino acid protein that localizes predominantly in the cytoplasm but translocates to the nucleus upon interaction with REP proteins. Existing as a homopentamer and consisting of one BTB (POZ) domain, KCTD5 associates with GRASP55, CUL-3 and ubiquitinated proteins. Interaction with CUL-3 suggests KCTD5 functions as a substrate adapter protein in some E3 ligase complexes.
Subunit:
Homopentamer. Interacts (via SLCterminus) with GRASP55/GORASP2. Interacts with CUL3 and with ubiquitinated proteins. Interacts with adeno-associated virus 2 (AASLV2) REP proteins.
Subcellular Location:
Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic, translocated to the nucleus upon interaction with Rep proteins.
Similarity:
Contains 1 BTB (POZ) domain.
Database links:
Entrez Gene: 54442 Human
Omim: 611285 Human
SwissProt: Q9NXV2 Human
Unigene: 61960 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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