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Rabbit Anti-TSPAN9/FITC Conjugated antibody
background:
The tetraspanin family is a group of cell surface proteins that regulate cell development, activation, growth and motility. Each member contains four hydrophobic domains and participates in the mediation of signal transduction. NET-5, also known as TSPAN9 (tetraspanin 9), is a 239 amino acid multi-pass membrane protein that belongs to the tetraspanin (TM4SF) family. NET-5 forms a complex with GPVI in the tetraspanin microdomains on the platelet surface, and is encoded by a gene that maps to human chromosome 12p13.33. Chromosome 12 encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.
Subunit:
Found in a complex with GP6.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in megakaryocytes and platelets.
Similarity:
Belongs to the tetraspanin (TM4SF) family.
Database links:
Entrez Gene: 10867 Human
Omim: 613137 Human
SwissProt: O75954 Human
Unigene: 504517 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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