Rabbit Anti-TET1/FITC Conjugated antibody

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Leukemia associated protein with a CXXC domain; CXXC 6; CXXC finger 6; CXXC type zinc finger protein 6; CXXC-type zinc finger protein 6; CXXC6; KIAA1676; LCX; Leukemia-associated protein with a CXXC domain; Methylcytosine dioxygenase TET1; Ten eleven tran

Cat:

SL8523R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human TET1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

235kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
TET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,136 amino acid protein that localizes to the nucleus and contains one CXXSLCtype zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.

Subunit:
Interacts with SIN3A; recruits the transcriptional co-repressor SIN3A to gene promoters.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in fetal heart, lung and brain, and in adult skeletal muscle, thymus and ovary.

Similarity:
Belongs to the TET family.
Contains 1 CXXSLCtype zinc finger.

Database links:

Entrez Gene: 80312 Human

Entrez Gene: 52463 Mouse

Entrez Gene: 309902 Rat

Omim: 607790 Human

SwissProt: Q8NFU7 Human

SwissProt: Q3URK3 Mouse

Unigene: 567594 Human

Unigene: 708977 Human

Unigene: 17774 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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