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Rabbit Anti-SMURF1/FITC Conjugated antibody
background:
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Acts by mediating ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members.
Subcellular Location:
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Similarity:
Contains 1 C2 domain.
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 2 WW domains.
Database links:
Entrez Gene: 57154 Human
Entrez Gene: 75788 Mouse
Omim: 605568 Human
SwissProt: Q9HCE7 Human
SwissProt: Q9CUN6 Mouse
Unigene: 189329 Human
Unigene: 27735 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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