background:
MuRF1 (RNF28), MuRF2 (RNF29) and MuRF3 (RNF30) are a specific class of RING finger proteins expressed in striated muscle tissues that act as signaling molecules and cytoskeletal adaptors. The MuRF proteins contain a conserved N-terminal RING domain and zinc-binding B-box motif in addition to two coiled-coil motifs in their central regions. In muscle cells, MuRF2 regulates gene expression and protein turnover. It localizes to the cytoplasm, but under atrophic conditions it is detected in the nucleus. MuRF2 can form oligomers with various other proteins, including titin and myosin, during sarcomere assembly. Endogenous MuRF2 associates with the sarcomeric M-band in cardiomyocytes. There are at least four isoforms of MuRF2.
Subunit:
Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Isoform 4 may not able to interact with isoform 1, isoform 2 and isoform 3. Probably interacts with TRIM63 and TRIM54.
Subcellular Location:
Cytoplasm. Nucleus. Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules.
Tissue Specificity:
Highly expressed in muscle. Low-level expression in liver.
Similarity:
Contains 1 B box-type zinc finger.
Contains 1 COS domain.
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 84675 Human
Entrez Gene: 381485 Mouse
Entrez Gene: 365751 Rat
Omim: 606469 Human
SwissProt: Q9BYV6 Human
SwissProt: Q5PQN5 Rat
Unigene: 85524 Human
Unigene: 35419 Mouse
Unigene: 76142 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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