Rabbit Anti-RNF62/MKRN2/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-RNF62/MKRN2/FITC Conjugated antibody

HSPC070； Makorin 2; Makorin ring finger protein 2; Makorin2; Makorin-2 MKRN 2; RING finger protein 62; RNF 62; RNF62; MKRN2_HUMAN; Probable E3 ubiquitin-protein ligase makorin-2; RING finger protein 62.

Cat:

SL9379R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human MKRN2/RNF62

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

47kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
The Makorins are a family of putative ribonucleoproteins containing two to four C3H zinc fingers that may confer RNA-binding. In addition, they contain a C3HC4 RING zinc finger that allows them to function as E3 ubiquitin ligases. Makorin-2, also known as RNF62, HSPC070 or MKRN2, is a widely expressed, evolutionarily conserved protein with four C3H-type zinc fingers (three at the N-terminus and one at the SLCterminus), one RING-type zinc finger and a cysteine and histidine motif similar to that found in Makorin-1. In Xenopus, Makorin-2 functions, via PI 3-kinase/Akt signaling, as a negative regulator of neurogenesis. In humans, Makorin-2 is overexpressed in various cancer cell lines, suggesting a possible role of Makorin-2 in tumor progression. In addition, Makorin-2 is co-expressed with Raf-1 in the same tissues and cell lines.

Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity).

Subcellular Location:
Nuclear

Tissue Specificity:
Widely expressed.

Similarity:
Contains 4 C3H1-type zinc fingers.
Contains 1 RING-type zinc finger.

Database links:

Entrez Gene: 2729 Human

Entrez Gene: 67027 Mouse

Entrez Gene: 297525 Rat

Omim: 608426 Human

SwissProt: Q9H000 Human

SwissProt: Q9ERV1 Mouse

SwissProt: Q5XI23 Rat

Unigene: 591666 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall