Rabbit Anti-TDRD9/FITC Conjugated antibody

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C14orf75; chromosome 14 open reading frame 75; HIG 1; HIG1; Hypoxia inducible HIG 1; MGC135025; Putative ATP dependent RNA helicase TDRD9; Putative ATP-dependent RNA helicase TDRD9; TDRD 9; Tdrd9; TDRD9_HUMAN ; Tudor domain containing 9; Tudor domain cont

Cat:

SL2185R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human TDRD9/HIG1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

155kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Probable ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with PIWIL4 and the piP-bodies suggests a participation in the secondary piRNAs metabolic process.

Function:
Probable ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with PIWIL4 and the piP-bodies suggests a participation in the secondary piRNAs metabolic process

Subunit:
Interacts with piRNA-associated proteins PIWIL1 and PIWIL4

Subcellular Location:
Cytoplasm. Nucleus. Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies.

Similarity:
Belongs to the DEAD box helicase family. DEAH subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.
Contains 1 Tudor domain.

Database links:

Entrez Gene: 12482 Human

Entrez Gene: 74691 Mouse

Entrez Gene: 299343 Rat

SwissProt: Q8NDG6 Human

SwissProt: Q14BI7 Mouse

SwissProt: Q3MHU3 Rat

Unigene: 21454 Human

Unigene: 60648 Mouse

Unigene: 126122 Rat

Unigene: 224769 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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