background:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Subunit:
Interacts with myosin regulatory light chain (MRLC) and TMEM4.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Ubiquitously expressed.
Post-translational modifications:
Autoubiquitinated.
Similarity:
Contains 1 FERM domain.
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 29116 Human
Entrez Gene: 218203 Mouse
Omim: 610082 Human
SwissProt: Q8WY64 Human
SwissProt: Q8BM54 Mouse
Unigene: 484738 Human
Unigene: 212855 Mouse
Unigene: 481228 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
