background:
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a SLCterminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]
Function:
Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the SLCterminus of proteins having the SLCterminal sequence Cys-aliphatic-aliphatic-X. Acts on the Rac1, Rac2, Rap1A and Rap1B proteins. The beta subunit is responsible for peptide-binding.
Subunit:
Heterodimer of an alpha and a beta subunit.
Similarity:
Belongs to the protein prenyltransferase subunit beta family.
Contains 4 PFTB repeats.
Database links:
Entrez Gene: 5229 Human
Entrez Gene: 225467 Mouse
Entrez Gene: 81746 Rat
Omim: 602031 Human
SwissProt: P5729 Human
SwissProt: Q8BUY9 Mouse
SwissProt: P53610 Rat
Unigene: 254006 Human
Unigene: 262096 Mouse
Unigene: 393044 Mouse
Unigene: 10031 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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