background:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity.The proteasome represents a large protein complex that exists inside all eukaryotes and archaea, and in some bacteria. The main function of proteasomes is to degrade unnecessary or damaged proteins by proteolysis. The most common form of the proteasome, known as the 26S Proteasome, contains one 20S Proteasome core particle structure and two 19S regulatory caps. The 20S Proteasome core is hollow and forms an enclosed cavity, where proteins are degraded, as well as openings at the two ends to allow the target protein to enter. The 20S Proteasome core particle contains many subunits, depending on the organism.
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity.
Subunit:
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic equivalent immune-specific subunit PSMB10. Interacts with HISLV1 TAT protein.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues.
Similarity:
Belongs to the peptidase T1B family.
Database links:
Entrez Gene: 5695 Human
Entrez Gene: 19177 Mouse
Entrez Gene: 100037992 Pig
Entrez Gene: 85492 Rat
Omim: 604030 Human
SwissProt: Q2TBP0 Cow
SwissProt: Q99436 Human
SwissProt: P70195 Mouse
SwissProt: A1XQU1 Pig
SwissProt: Q9JHW0 Rat
Unigene: 213470 Human
Unigene: 389251 Mouse
Unigene: 3846 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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