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Rabbit Anti-Proteasome 20S alpha 5/FITC Conjugated antibody
background:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subunit:
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. PSMA5 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Expressed in fetal brain (at protein level).
Similarity:
Belongs to the peptidase T1A family.
Database links:
Entrez Gene: 5686 Human
Entrez Gene: 26442 Mouse
Entrez Gene: 29672 Rat
Omim: 176844 Human
SwissProt: P28066 Human
SwissProt: Q9Z2U1 Mouse
SwissProt: P34064 Rat
Unigene: 485246 Human
Unigene: 208883 Mouse
Unigene: 1276 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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