Rabbit Anti-Proteasome 20S alpha 2/FITC Conjugated antibody

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20S Proteasome α2; HC3; Macropain subunit C3; MU antibody Multicatalytic endopeptidase complex subunit C3; PMSA2; Proteasome (prosome macropain) subunit alpha type 2; Proteasome alpha 2 subunit; Proteasome component C3; Proteasome subunit alpha type 2; Pr

Cat:

SL9351R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Proteasome 20S alpha 2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

26kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.

Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. PSMA2 may have a potential regulatory effect on another component(s) of the proteasome complex through tyrosine phosphorylation.

Subunit:
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

Subcellular Location:
Cytoplasm. Nucleus. Cytoplasm, P-body (By similarity). Note=Co-localizes with TRIM5 in the cytoplasmic bodies (By similarity).

Post-translational modifications:
Phosphorylated on tyrosine residues; which may be important for nuclear import (By similarity).

Similarity:
Belongs to the peptidase T1A family.

Database links:

Entrez Gene: 5683 Human

Entrez Gene: 19166 Mouse

Entrez Gene: 29669 Rat

Omim: 176842 Human

SwissProt: P25787 Human

SwissProt: P49722 Mouse

SwissProt: P17220 Rat

Unigene: 333786 Human

Unigene: 252255 Mouse

Unigene: 1617 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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