background:
ACLP2 (acid phosphatase-like 2), also known as UNQ370 or PRO706, is a 96 amino acid secreted protein that functions to catalyze the H2O-dependent conversion of a phosphate monoester to an alcohol and a phosphate. Expressed as two alternatively spliced isoforms, ACPL2 is encoded by a gene that maps to chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
Subcellular Location:
Secreted.
Similarity:
Belongs to the histidine acid phosphatase family.
Database links:
Entrez Gene: 92370 Human
Entrez Gene: 235534 Mouse
Entrez Gene: 315939 Rat
SwissProt: Q8TE99 Human
SwissProt: Q8SHA9 Mouse
SwissProt: Q66H78 Rat
Unigene: 657887 Human
Unigene: 233031 Mouse
Unigene: 9589 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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