background:
MARCH4, an E3 ubiquitin protein ligase, may mediate ubiquitination of MHC I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin protein ligases accept ubiquitin from an E2 ubiquitin conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Function:
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHSLCI and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Subcellular Location:
Golgi apparatus membrane; Multipass membrane protein.
Tissue Specificity:
Expressed in brain and placenta.
Similarity:
Contains 1 RING-CH-type zinc finger.
Database links:
Entrez Gene: 57574 Human
Entrez Gene: 381270 Mouse
Entrez Gene: 367295 Rat
Omim: 608208 Human
SwissProt: Q9P2E8 Human
SwissProt: Q80TE3 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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