Rabbit Anti-ITPR3/FITC Conjugated antibody

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IP3R-III; IP3 receptor isoform 3; 4 antibody 5-trisphosphate receptor; 5-trisphosphate receptor type 3; FLJ36205; Inositol 1; Inositol 1,4,5 trisphosphate receptor type 3; IP3 receptor; IP3R 3; IP3R; IP3R3; ITPR 3; ITPR3; ITPR3_HUMAN; Type 3 inositol 1; T

Cat:

SL6471R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Cow,Horse,Rabbit,d)

Immunogen：

KLH conjugated synthetic peptide derived from human ITPR3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

294kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.

Function:
Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.

Subunit:
Homotetramer. Interacts with SIGMAR1, PML, AKT1, TRPC1, TRPC3 and TRPC4 (By similarity). Interacts with CABP1. Interacts with TMBIM4/LFG4.

Subcellular Location:
Endoplasmic reticulum membrane.

Tissue Specificity:
Expressed in intestinal crypt and villus epithelial cells.

Similarity:
Belongs to the InsP3 receptor family.
Contains 5 MIR domains.

Database links:

Entrez Gene: 317697 Cow

Entrez Gene: 3708 Human

Entrez Gene: 16438 Mouse

Entrez Gene: 25262 Rat

Omim: 147265 Human

SwissProt: Q9TU34 Cow

SwissProt: Q14643 Human

SwissProt: P11881 Mouse

SwissProt: P29994 Rat

Unigene: 567295 Human

Unigene: 715765 Human

Unigene: 227912 Mouse

Unigene: 2135 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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