background:
Spo11 is a type II topoisomerase that is thought to generate the chromosome breaks that initiate meiotic recombination. The Spo11 protein initiates meiotic recombination by generating DNA double-strand breaks (DSBs) and is required for meiotic synapsis in S. cerevisiae. The DSBs are located mostly in promoter regions, where the chromatin is in an open configuration, and cluster in domains along the chromosome. Expression of the Spo11 is detected mainly in the testis, in agreement with its predicted function in the initiation of meiotic recombination. Disruption of Spo11 leads to severe gonadal abnormalities from defective meiosis and results in infertility.
Function:
Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity).
Subcellular Location:
Nuclear
Tissue Specificity:
Highly expressed in testis.
Similarity:
Belongs to the TOP6A family.
Database links:
Entrez Gene: 23626 Human
Entrez Gene: 26972 Mouse
Entrez Gene: 100125974 Pig
Entrez Gene: 366261 Rat
Omim: 605114 Human
SwissProt: Q9Y5K1 Human
SwissProt: Q9WTK8 Mouse
Unigene: 159737 Human
Unigene: 23495 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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