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Rabbit Anti-ANKRD17/FITC Conjugated antibody
background:
ANKRD17 is a 2,603 amino acid protein that contains 25 ankyrin repeats and one KH domain. ANKRD17 is expressed in bone marrow and is thought to be involved in liver development. ANKRD17 localizes to the cytoplasm and the nucleus. ANKRD17 exists as five alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 4. Representing approximately 6% of the human genome, chromosome 4 contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Chromosome 4 reportedly contains the largest gene deserts (regions of the genome with no protein encoding genes) and has one of the two lowest recombination frequencies of the human chromosomes.
Function:
Earliest specific in situ marker of hepatic differentiation during embryogenesis, useful for characterization of inductive events involved in hepatic specification (By similarity). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease).
Subunit:
Interacts with VP1 capsid protein of enterovirus 71 (EV71).
Subcellular Location:
Cytoplasm. Nucleus. Detected around the nucleolus.
Tissue Specificity:
Expressed in bone marrow.
Similarity:
Contains 25 ANK repeats.
Contains 1 KH domain.
Database links:
Entrez Gene: 9743 Human
Omim: 608541 Human
SwissProt: A7KAX9 Human
Unigene: 88379 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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