background:
The development and differentiation of plasma cells, which are terminally differentiated B-cells, are induced by Blimp-1 (B lymphocyte-induced maturation protein, also designated PRDI-SF1). Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development. Alone, Blimp-1 is sufficient to trigger terminal B-cell differentiation. Blimp-1 upregulates the expression of syndecan-1 and J chain, represses IFN-b gene transcription and associates with HDAC to recruit it to DNA, thereby repressing c-myc. Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells, as well as in long-lived, bone marrow plasma cells. The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage, whereas immature and partially activated cells are eliminated.
Function:
Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells.
Subunit:
Interacts with PRMT5.
Subcellular Location:
Nucleus. Cytoplasm.
Similarity:
Contains 4 C2H2-type zinc fingers.
Contains 1 SET domain.
Database links:
Entrez Gene: 538384 Cow
Entrez Gene: 481947 Dog
Entrez Gene: 639 Human
Entrez Gene: 12142 Mouse
Entrez Gene: 100154284 Pig
Entrez Gene: 309871 Rat
Omim: 603423 Human
SwissProt: O75626 Human
SwissProt: Q60636 Mouse
Unigene: 47223 Human
Unigene: 960 Mouse
Unigene: 8012 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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