Rabbit Anti-USP9X/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-USP9X/FITC Conjugated antibody

X chromosome; X-linked; Deubiquitinating enzyme FAF X; Deubiquitinating enzyme FAF-X; DFFRX; Fafl; Fam; Fat facets homolog; Fat facets in mammals; Fat facets protein related X linked; Fat facets protein related X-linked; Fat facets protein-related; hFAM;

Cat:

SL9266R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from hu USP9X

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

292kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Function:
Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33.

Subunit:
Interacts with SMAD4, MARK4, NUAK1 and BIRC5/survivin.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Widely expressed in embryonic and adult tissues.

Similarity:
Belongs to the peptidase C19 family.

Database links:

Entrez Gene: 8239 Human

Entrez Gene: 22284 Mouse

Entrez Gene: 363445 Rat

Omim: 300072 Human

SwissProt: Q93008 Human

SwissProt: P70398 Mouse

Unigene: 77578 Human

Unigene: 242646 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall