background:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF32 (RING finger protein 32), also known as HSD15 or FKSG33, is a 362 amino acid cytoplasmic protein that contains one IQ domain and two RING-type zinc fingers. Highly expressed in testis with lower expression levels in ovary tissue, RNF32 is thought to play a role in spermatogenesis, specifically contributing to the growth and maturation of round spermatids. Six isoforms of RNF32 exist due to alternative splicing events.
Function:
May play a role in sperm formation.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Highly expressed in testis, less abundant in ovary.
Similarity:
Contains 1 IQ domain.
Contains 2 RING-type zinc fingers.
Database links:
Entrez Gene: 140545 Human
Omim: 610241 Human
SwissProt: Q9H0A6 Human
Unigene: 446194 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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