background:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF215 (ring finger protein 215), is a 377 amino acid multi-pass membrane protein containing one RING-type zinc finger. The gene encoding RNF215 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.
Subcellular Location:
Membrane; Multi-pass membrane protein (Potential).
Similarity:
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 200312 Human
Entrez Gene: 71673 Mouse
SwissProt: Q9Y6U7 Human
SwissProt: Q5SPX3 Mouse
Unigene: 592194 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|