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Rabbit Anti-RNF125/FITC Conjugated antibody
background:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. TRASLC1 (T-cell RING activation protein 1), also known as RNF125 (ring finger protein 125) or E3 ubiquitin-protein ligase RNF125, is a 232 amino acid novel E3 ubiquitin ligase that functions as a positive regulator in the T-cell receptor signaling pathway. Expressed predominantly in lymphoid tissues such as spleen, thymus and bone marrow, TRASLC1 has been found to inhibit pathogen-induced cytokine production and down-regulates HIV replication.
Function:
E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.
Tissue Specificity:
Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells.
Similarity:
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 54941 Human
Entrez Gene: 67664 Mouse
Entrez Gene: 361296 Rat
Omim: 610432 Human
SwissProt: Q96EQ8 Human
SwissProt: Q9D9R0 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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