Rabbit Anti-RNF34/FITC Conjugated antibody

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Caspase regulator CARP1; CARP 1; CARP-1; CARP1; Caspase regulator CARP1; Caspases-8 and -10-associated RING finger protein 1; E3 ubiquitin-protein ligase RNF34; FYVE-RING finger protein Momo; hRFI; Human RING finger homologous to inhibitor of apoptosis pr

Cat:

SL9242R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human RNF34

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

42kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol-5-phosphate and phosphatidylinositol-3-phosphate.

Function:
Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate.

Subunit:
Interacts with DNAJA3 (Potential). Interacts with CASP8 and CASP10.

Subcellular Location:
Nucleus speckle. Endomembrane system; Peripheral membrane protein.

Tissue Specificity:
Ubiquitous. Detected in heart, brain, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, colon and leukocytes.

Post-translational modifications:
Auto-ubiquitinated (in vitro) (By similarity).
Proteolytically cleaved by caspases upon induction of apoptosis by TNF.

Similarity:
Contains 1 FYVE-type zinc finger.
Contains 1 RING-type zinc finger.
Contains 2 SAP domains.

Database links:

Entrez Gene: 80196 Human

Entrez Gene: 80751 Mouse

Entrez Gene: 282845 Rat

Omim: 608299 Human

SwissProt: Q5E9J6 Cow

SwissProt: Q969K3 Human

SwissProt: Q99KR6 Mouse

SwissProt: Q6AYH3 Rat

Unigene: 292804 Human

Unigene: 388529 Mouse

Unigene: 14904 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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