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Home > Product > Antibody > Rabbit Anti-RNF23/FITC Conjugated antibody
Ring finger protein 23; RNF23; Testis abundant finger protein; TFP; TFP RING FINGER PROTEIN 23; TRIM39; Tripartite motif containing 39; TRI39_HUMAN.
Cat:
SL9238R-FITC
Species Reactivity：
(predicted: Human,Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human RNF23
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
60kDa
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Product PDFs
Datasheet:


background:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF23 (RING finger protein 23), also known as tripartite motif-containing protein 39 (TRIM39) or testis-abundant finger protein, is a 518 amino acid protein belonging to the TRIM/RBCC family that is known to interact with MOAP1. Ubiquitously expressed and existing as two alternatively spliced isoforms, RNF23 is found at highest levels in spleen, testis, brain, kidney, liver, heart and skeletal muscle. RNF23 typically localizes to cytosol but shifts to mitochondria upon co-localization with MOAP1, a short-lived, pro-apoptotic protein which RNF23 prevents from becoming poly-ubiquitinated and degraded, thereby facilitating apoptosis. RNF23 contains one B box-type zinc finger, a B30.2/SPRY domain and a single RING-type zinc finger.

Function:
E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/SLCCdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.

Subunit:
Interacts with MOAP1.

Subcellular Location:
Cytoplasm, cytosol. Mitochondrion. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when co-localized with MOAP1.

Tissue Specificity:
Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.

Post-translational modifications:
Autoubiquitinated.

Similarity:
Belongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 B30.2/SPRY domain.
Contains 1 RING-type zinc finger.

Database links:

Entrez Gene: 56658 Human

Entrez Gene: 79263 Mouse

Entrez Gene: 309591 Rat

Omim: 605700 Human

SwissProt: Q9HCM9 Human

SwissProt: Q9ESN2 Mouse

SwissProt: Q6MFZ5 Rat

Unigene: 413493 Human

Unigene: 40624 Mouse

Unigene: 229996 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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