background:
The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM61 (Tripartite motif-containing protein 61), also known as RNF35 (RING finger protein 35), is a 209 amino acid protein that contains a variety of domains that are characteristic to TRIM proteins, including a RING-type zinc finger and a B box-type zinc finger. In mice, TRIM61 is temporarily transcribed in the early embryo, but then is permanently silenced before the blastocyst stage of development. Transcription of TRIM61 is positively regulated by nuclear factor Y (NF-Y). The gene encoding TRIM61 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.
Function:
May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity.
Subunit:
Interacts with NEDD8.
Tissue Specificity:
Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract.
Similarity:
Belongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 135644 Human
Entrez Gene: 195359 Mouse
Entrez Gene: 365528 Rat
SwissProt: Q6P9F5 Human
SwissProt: Q3UWA4 Mouse
SwissProt: Q6MFY8 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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