background:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF36 (ring finger protein 36), also known as Rines, is a 592 single-pass membrane protein that contains a single RING-type zinc finger. Expressed as three alternatively spliced isoforms, RNF36 is well conserved among vertebrates. RNF36 is expressed in brain, kidney, testis and uterus and localizes to the endoplasmic reticulum. RNF36 is an E3 ubiquitin ligase involved in the ubiquitin-proteasome pathway. RNF36 is encoded by a gene located on human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm, or of chromosome 5 altogether, is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
Function:
E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.
Subunit:
Interacts with ZIC2.
Subcellular Location:
Membrane; Single-pass membrane protein.
Similarity:
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 285671 Human
SwissProt: Q86T96 Human
Unigene: 657843 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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