background:
RNF166 is a 237 amino acid protein that contains one RING-type zinc finger and a UIM (ubiquitin-interacting motif) repeat. Existing as two alternatively spliced isoforms, RNF166 is encoded by a gene that maps to human chromosome 16q24.3. Chromosome 16 encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Similarity:
Contains 1 RING-type zinc finger.
Contains 1 UIM (ubiquitin-interacting motif) repeat.
Database links:
Entrez Gene: 115992 Human
Entrez Gene: 68718 Mouse
Entrez Gene: 365022 Rat
SwissProt: Q96A37 Human
SwissProt: Q3U9F6 Mouse
SwissProt: Q6J1I7 Rat
Unigene: 52764 Human
Unigene: 34356 Mouse
Unigene: 458434 Mouse
Unigene: 43927 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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