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Rabbit Anti-RNF156/FITC Conjugated antibody
background:
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
Function:
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
Subunit:
Interacts with MC1R and MC4R, but not with TBXA2R. Interacts with TSG101. Interacts with mislocalized cytosolically exposed PRNP; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement (By similarity).
Subcellular Location:
Cytoplasm. Cell membrane.
Post-translational modifications:
Autoubiquitinated in vitro (By similarity).
Similarity:
Contains 1 RING-type zinc finger.
Database links:
Entrez Gene: 23295 Human
Entrez Gene: 17237 Mouse
Entrez Gene: 302938 Rat
Omim: 607559 Human
SwissProt: O60291 Human
SwissProt: Q9D074 Mouse
SwissProt: Q5XIQ4 Rat
Unigene: 526494 Human
Unigene: 291326 Mouse
Unigene: 15530 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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