Rabbit Anti-RNF41/FITC Conjugated antibody

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E3 ubiquitin protein ligase NRDP1; Fetal Liver RING finger protein; FLRF; MGC45228; Neuregulin receptor degradation protein 1; NRDP1; Ring Finger Protein 41; SBBI03; RNF41_HUMAN.

Cat:

SL9224R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human RNF41

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

36kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
RNF41 contains one RING-type zinc finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. It acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins, such as ERBB3. RNF41 has been detected in ovary, testis and prostate.

Function:
Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.

Subunit:
Interacts with USP8, ERBB3, PARK2 and BIRC6. Interacts with CSF2RB, EPOR, IL3RA, MYD88 and TBK1 (By similarity).

Tissue Specificity:
Detected in ovary, testis and prostate.

Post-translational modifications:
Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.

Similarity:
Contains 1 RING-type zinc finger.
Contains 1 SIAH-type zinc finger.

Database links:

Entrez Gene: 10193 Human

Entrez Gene: 67588 Mouse

Entrez Gene: 362814 Rat

SwissProt: Q9H4P4 Human

SwissProt: Q8SH75 Mouse

Unigene: 524502 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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