background:
Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChR?, also known as LNCR2, PAOD2, NACHRA3 or CHRNA3, is a 505 amino acid multi-pass membrane protein that belongs to the ligand-gated ion channel receptor family and may play a role in neurotransmission.
Function:
After binding acetylcholine, the AChR responds by anextensive change in conformation that affects all subunits andleads to opening of an ion-conducting channel across the plasmamembrane.
Subunit:
Neuronal AChR is composed of two different types ofsubunits: alpha and beta. Alpha-3 subunit can be combined to beta-2or beta-4 to give rise to functional receptors. Interacts withRIC3; which is required for proper folding and assembly.
Subcellular Location:
Cell junction, synapse, postsynaptic cellmembrane; Multi-pass membrane protein. Cell membrane; Multi-passmembrane protein.
Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9)family. Acetylcholine receptor (TC 1.A.9.1) subfamily.Alpha-3/CHRNA3 sub-subfamily.
Database links:
Entrez Gene: 386578 Chicken
Entrez Gene: 282702 Cow
Entrez Gene: 1136 Human
Entrez Gene: 110834 Mouse
Entrez Gene: 25101 Rat
Omim: 118503 Human
SwissProt: P09481 Chicken
SwissProt: Q07263 Cow
SwissProt: P32297 Human
SwissProt: Q8R4G9 Mouse
SwissProt: P04757 Rat
Unigene: 89605 Human
Unigene: 63569 Mouse
Unigene: 10996 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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