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Rabbit Anti-SERPINB3/FITC Conjugated antibody
background:
Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine prote-ases, such as neutrophil elastase.SCCA is transcribed by two nearly identical genes (SCCA1 and SCCA2), and is mainly produced as SCCA1. The human SCCA1 gene encodes a 390 amino acid protein that was originally isolated from a metastatic cervical squamous cell carcinoma.
Function:
May act as a protease inhibitor to modulate the host immune response against tumor cells.
Subcellular Location:
Cytoplasm. Seems to also be secreted in plasma by cancerous cells but at a low level.
Tissue Specificity:
Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).
Similarity:
Belongs to the serpin family. Ov-serpin subfamily.
Database links:
Entrez Gene: 6317 Human
Omim: 600517 Human
SwissProt: P29508 Human
Unigene: 227948 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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