Rabbit Anti-CSPP1/FITC Conjugated antibody

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Centrosome and spindle pole associated protein 1; CSPP 1; CSPP; FLJ22490; FLJ38886; CSPP1_HUMAN.

Cat:

SL9208R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human CSPP1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

146kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and provide a site for concerted regulation of cell cycle progression. Duplication of centrosomes occurs once during each cell cycle and requires proper mitotic spindle formation and chromosome segregation. Defects in centrosome duplication or function are linked to many human diseases, including various forms of cancer. The centrosome and spindle pole-associated protein 1 (CSPP1) interacts with centrosomes and microtubules and may play a role in the regulation of G(1)/S-phase progression and spindle assembly. Two isoforms of CSPP1 exist as a result of alternative splicing events. Isoform 1 expression increases throughout the cell cycle and peaks in G2/M phase, whereas isoform 2 expression is highest in G1 phase and decreases thereafter.

Function:
May play a role in cell-cycle-dependent microtubule organization.

Subunit:
Interacts with PLEKHG6

Subcellular Location:
Cytoplasm; cytoskeleton; centrosome. Cytoplasm; cytoskeleton; spindle. Note: Associated with mitotic spindles.

Tissue Specificity:
Detected in testis.

Post-translational modifications:
Phosphorylated. Phosphorylation increases in colcemide-treated cells.

Database links:

Entrez Gene: 79848 Human

Omim: 611654 Human

SwissProt: Q1MSJ5 Human

Unigene: 370147 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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