background:
Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine.
Function:
Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine.
Subunit:
Interacts with PRDX1; forms a mixed-disulfide with PRDX1, leading to disrupt intramolecular disulfide bond between Cys-25 and Cys-571 (By similarity).
Subcellular Location:
Endomembrane system. Cytoplasm; perinuclear region. Cell projection; growth cone. In a punctate perinuclear pattern.
Post-translational modifications:
Intramolecular disulfide bond between Cys-25 and Cys-571 is reduced by PRDX1 (By similarity).
Similarity:
Belongs to the glycerophosphoryl diester phosphodiesterase family.
Contains 1 GDPD domain.
Database links:
Entrez Gene: 81544 Human
Entrez Gene: 233552 Mouse
Entrez Gene: 100627912 Pig
Entrez Gene: 499211 Rat
Omim: 609632 Human
SwissProt: Q8WTR4 Human
SwissProt: Q128M6 Mouse
Unigene: 503297 Human
Unigene: 286317 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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