background:
May function as a transcription repressor. Suppresses osteogenic effects of RUNX2. Binds to 5'-CCACA-3' core sequence. May be involved in osteoblastic differentiation.
Subunit:
Interacts with RUNX2. Binds consensus element OSE2
Subcellular Location:
Nucleus
Tissue Specificity:
Expressed in kidney and skeletal muscle. Very low expression in brain and heart.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 11 C2H2-type zinc fingers.
Contains 1 KRAB domain.
Database links:
Entrez Gene: 147011 Human
SwissProt: Q8NCQ7 Human
Unigene: 207471 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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