background:
The transcriptional enhancer factor-1 (TEF-1) family of transcription factors regulate tissue-specific gene expression in muscle and placenta. The mechanism whereby TEF-1 confers tissue specificity depends largely on the interaction of TEF-1 with tissue-specific cofactors. Transcription cofactor Vgl-3 (vestigial-like protein 3), also known as colon carcinoma related protein, is a 326 amino acid nuclear protein that may act as a specific coactivator for the mammalian transcription elongation factors. Both Vgl-1 and Vgl-3 are enriched in placenta, whereas Vgl-2 is expressed in differentiating somites and branchial arches during embryogenesis and is skeletal-muscle specific in adult tissues. There are two isoforms of Vgl-3 that are produced as a result of alternative splicing events.
Function:
May act as a specific coactivator for the mammalian TEFs
Subcellular Location:
Nucleus
Tissue Specificity:
Enriched in placenta.
Similarity:
Belongs to the vestigial family.
Database links:
Entrez Gene: 389136 Human
Entrez Gene: 73569 Mouse
Omim: 609196 Human
SwissProt: A8MV65 Human
SwissProt: P85442 Mouse
Unigene: 714347 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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