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Rabbit Anti-RNF17/FITC Conjugated antibody
background:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF17 (ring finger protein 17) or tudor domain-containing protein 4, TDRD4, SPATA23, Mmip-2 or FLJ11045, is a testis-specific protein and and novel key regulator of spermiogenesis containing 1,623 amino acids. By distributing Mad proteins to the cytoplasm, RNF17 regulates the transcriptional activity of c-Myc. Although showing localization in the nucleus, RNF17 is predominantly observed in cytoplasm and is a component of a novel nuage found in male germ cells. The gene encoding RNF17 maps to human chromosome 13q12.12 and encodes one RING-type zinc finger and four tudor domains. As a result of alternative splice events, five RNF17 isoforms exisit.
Function:
Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity).
Subunit:
Interacts with MXD1, MXD3, MXD4, MXI1 and PIWIL1. Self-associates (By similarity).
Subcellular Location:
Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly found in the cytoplasm. Component of a nuage in male germ cells (an electron-dense spherical cytoplasmic body present in late pachytene and diplotene spermatocytes and in elonging spermatids) (By similarity).
Tissue Specificity:
Testis specific.
Similarity:
Contains 1 RING-type zinc finger.
Contains 4 Tudor domains.
Database links:
Entrez Gene: 56163 Human
Omim: 605793 Human
SwissProt: Q9BXT8 Human
Unigene: 97464 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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