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Rabbit Anti-RNF14/FITC Conjugated antibody
background:
Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.
Function:
Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.
Subunit:
Interacts with the ubiquitin-conjugating enzymes UBE2E1 and UBE2E2. Interacts with AR/androgen receptor; testosterone- and RNF6-regulated it promotes AR transcriptional activity.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Widely expressed.
Post-translational modifications:
RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination.
Similarity:
Belongs to the RBR family. RNF14 subfamily.
Contains 1 IBR-type zinc finger.
Contains 2 RING-type zinc fingers.
Contains 1 RWD domain.
Database links:
Entrez Gene: 9604 Human
Entrez Gene: 56736 Mouse
Entrez Gene: 619577 Rat
Omim: 605675 Human
SwissProt: Q9UBS8 Human
SwissProt: Q9JI90 Mouse
Unigene: 483616 Human
Unigene: 228903 Mouse
Unigene: 115357 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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